Cardiovasculaire Geneeskunde.nl

ASN 2010 - Update in nefrologische aandoeningen

Slides (presentatie) - 2 sep. 2010

Update in nefrologische aandoeningen:
- IgA nefropathie
- Multipele myelomen

Dr. M.A. van den Dorpel
Maasstad Ziekenhuis, Rotterdam

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Update in nefrologische aandoeningen

Multiple myeloom

MGUS en Multiple myeloma

An antibody molecule showing heavy and light chain structure, together with free κ and λ light chains

Serum FLC concentrations in patients with CKD


Renal pathologies associated with different plasma cell dyscrasias

MGUS en Multiple myeloma

Sensitivity of monoclonal gammopathy screening panels

Screening algorithm for suspected monoclonal gammopathies

Renal pathologies associated with different plasma cell dyscrasias

MM en nierinsufficientie

MM en nierinsufficientie

Plasmaferese bij MM





Free light chain removal

Table 2. Summary of the demographics and presenting features of study population Feature Study group (n 19) Age (years) 60 (38 to 81) Male gender (%) 74% Presenting creatinine (uM) 714 (427 to 1508) Presenting eGFR 7 (3 to 13) Patients with FLCs (%) 50% Presenting serum FLC concentration, g/L 2.6 (0.8 to 69) Data are shown as median (range). eGFR, estimated glomerular filtration rate (ml/min/1.73 m2), calculated by the 4-v MDRD

FLC reduction

Renal recovery rates of patients who received chemotherapy and FLC removal hemodialysis. Fourteen of the 19 patients who received FLC removal HD became independent of dialysis at a median of 28 d (range 13 to 120).

Kaplan-Meier survival analysis of patients treated with chemotherapy and FLC removal HD. Patients who developed complications requiring early interruption of chemotherapy (solid line, n=6) had a significantly reduced survival compared with patients who received uninterrupted chemotherapy (broken line, n=13); P <0.001.

[SA-PO2170] Gadolinium Contrast Stimulates Multiple Myeloma Growth Sundararaman Swaminathan, Mariateresa Fulciniti, Prajwal Chevireddy, Sudhir V. Shah, Neriman Gokden, Nikhil Munshi Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR; Pathology, University of Arkansas for Medical Sciences, Little Rock, AR; Dana-Farber Cancer Institute, Boston, MA

IgA nefropathie

IgA nefropathie

[TH-PO855] Intra-Renal Expression of microRNAs in Patients with IgA Nephropathy Gang Wang, Bonnie C. H. Kwan, Fernand M. M. Lai, Paul C. L. Choi, Kai-Ming Chow, Philip K. T. Li, Cheuk-Chun Szeto Department of Medicine & Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong; Department of Medicine & Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong

IgA nefropathie

Does a New IgA Nephropathy Clinicopathological Classification Have the Same Value in Children as in Adults? Rosanna Coppo, Stéphan Tryanov, Daniel Cattran, Terence Cook, John Feehally, Ian Roberts, Alessandro Amore, Roberta Camilla, Ronald Hogg, Francesco Emma, Norishige Yoshikawa Working Group of the International Society IgA Nephropathy Network and Renal Pathology Society Although C had significantly less chronic lesions and more endocapillary lesions, the predictive value of each variable on renal function decline was not influenced by age at biopsy (p>0.1 for interaction term).

Nieuwe therapeutische opties?

Nieuwe therapeutische opties?

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