Longembolieën verhogen risico subarachnoïdale bloedingen

Pulmonary embolism linked with long-term subarachnoid hemorrhage risk

J Thromb Haemost 2010; 8: 1710–1715.

Pulmonary embolism is associated with an increased long-term risk for subarachnoid hemorrhage, researchers have discovered.

The risk of this type of stroke was also elevated in the year after deep vein thrombosis, report Henrik Sørensen (Aarhus University Hospital, Denmark) and colleagues.

Venous thromboembolism predicts the subsequent risk for ischemic stroke and intracerebral hemorrhage, but it is not known whether it is also a risk factor for subarachnoid hemorrhage, say the researchers.

To investigate further, they studied data from the National Registry of Patients, which has recorded nearly all discharges from Danish acute care and non-psychiatric hospitals since the late 1970s.

The team identified 97,558 patients with a hospital diagnosis of venous thromboembolism between 1997 and 2007, and compared them with 453,406 population-based control individuals.

There was a significantly increased risk for subarachnoid hemorrhage among individuals with pulmonary embolism, both during the first year of follow-up (relative risk [RR]=2.69) and during follow-up of between 2 and 20 years (RR=1.40).

Patients with deep vein thrombosis also had an increased risk for subarachnoid hemorrhage during the first year of follow-up (RR=1.91), but this did not remain significant during later follow-up.

Reporting in the Journal of Thrombosis and Haemostasis, the researchers conclude: "We found evidence that pulmonary embolism is associated with an increased long-term risk of subarachnoid hemorrhage.

"Common undetected risk factors or pathways affecting the vessel wall are most likely responsible for the association. Further studies are needed to clarify the association and evaluate its implications for clinical practice."

Bron: MedWire

Abstract