 | | Prevalence of DHF |
|  | | Mortality in SHF and DHF |
|
 | | DHF?? |
|  | | Eur Heart J 2011;32:670 |
|
 | | 2009 update of ACC/AHA 2005 guidelines on HF |
|  | | Distinct remodeling in DHF vs SHF |
|
 | | Distinct myocardial structural characteristics in DHF vs SHF |
|  | | Eur Heart J 2007;28:2539 |
|
 | | Invasive diagnosis of DHF |
|  | | Invasive diagnosis of DHF |
|
 | | DHF: any change in pre- or afterload induces larger shifts in BP |
|  | | JACC 2009;54:410; JACC Img 2008;1:366 |
|
 | | DHF: systolic (l,r) strain, apical rotation; and delayed untwisting |
|  | | DHF: exertional dyspnea with exercise tolerance |
|
 | | Circulation 2006;114:2138; Eur Heart J 2011;32:670 |
|  | | RISK FACTORS |
|
 | | Risk factors for diastolic dysfunction |
|  | | JACC 2006;47:76; JACC 2007;50:768 |
|
 | | Risk factors for diastolic dysfunction |
|  | | Risk factors for diastolic dysfunction |
|
 | | Risk factors for diastolic dysfunction |
|  | | Risk factors for diastolic dysfunction |
|
 | | MONICA Augsburg |
|  | | Risk factors for diastolic dysfunction |
|
 | | Risk factors for diastolic dysfunction |
|  | | Metabolic syndrome - Definitions |
|
 | | Risk factors for diastolic dysfunction |
|  | | DHF pathophysiology |
|
 | | Extracellular matrix and cardiomyocytes determine myocardial |
|  | | Disturbances in cardiomyocyte Ca2+ handling can impair relaxation |
|
 | | Impaired myocardial energetics in DHF |
|  | | Extracellular matrix and cardiomyocytes determine myocardial |
|
 | | Increased interstitial fibrosis in hypertensive heart disease |
|  | | CVF |
|
 | | ACE-I /ARBs |
|  | | Discordant treatment outcome in SHF vs DHF |
|
|
|
|
|
 | | Biophys J 2007;93:1719 |
|  | | Biophys J 2007;93:1719 |
|
 | | Stiff “spring” |
|  | | Titin regulates cardiomyocyte intrinsic stiffness |
|
|
|
 | | Antiox & Redox Signal 2008;10:1115 |
|  | | Van Heerebeek et al, Circulation 2008;117:43 |
|
 | | DHF treatment options |
|  | | Roadmap for treatment of DHF |
|
 | | Spironolactone in DHF |
|  | | PDE5-I; ISDN-Hydralaz; |
|
 | | Nesiritide in acute HF |
|  | | PDE5-inhibition with sildenafil in SHF |
|
 | | Statins;PDE5-I |
|  | | Statins in DHF |
|
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