| New targets in lipid management |
| | Novel Approaches to Modify Lipids and Lipoproteins |
|
| Statin Prescription in the UK |
| | Percentage of the UK-population with TC > 5 mmol/l |
|
| All-Cause Mortality in the UK in those < 75 Years |
| | New Approaches to LDL Reduction |
|
| Mipomersen: Apo B-100 as a Target |
| | Overview of Mipomersen |
|
| Antisense |
| | Heterozygous Familial Hypercholesterolemia |
|
| Mipomersen Significantly Reduced LDL-C |
| | Distribution of LDL-C % Change From Baseline |
|
| The Rationale |
| | Selective Thyroid Receptor Agonist Provides New Treatment Opportunities |
|
| Eprotirome is… |
| | Eprotirome Monotherapy Efficiently Lowers LDL-C |
|
| LDL-C Mean % Change from Baseline |
| | PCSK9 Rapid Pace of Research |
|
| New Approaches for Raising HDL |
| | CETP Levels and CAD risk |
|
| Anacetrapib Dose Ranging Study |
| | Future |
|
| Niacin Flushing Pathway |
| | An Overview of the Niacin-Induced Flushing Pathway |
|
| Factorial Study: Lipid Efficacy |
| | HPS2-THRIVE |
|
| ApoA1 Based Therapies |
| | Cerenis HDL (CER-001)Homogeneous Drug Product |
|
| CER-001 Mobilizes Cholesterol in Rabbits |
| | CHI SQUARE Study Design |
|
| CHI-SQUARE Study Design |
| | IVUS clinical trial using selective delipidated HDL |
|
| IVUS Clinical Trial Using Selective Delipidated HDL |
| | Results of the IVUS Clinical Trial Using Selective Delipidated HDL |
|
| New Approaches for Reduction of TG rich Lipoproteins |
| | Apolipoprotein C-III Key Regulator of Serum Triglyceride Levels |
|
| Dose-dependent Reduction in Hepatic ApoC-III mRNA Levels |
| | Changes in Major Lipid Classes Over 12 Weeks in HTG Rhesus Plasma |
|
| New Approaches for Reduction of Inflammation |
| | The Balance of IL-1 and IL-1Ra |
|
| Canakinumab |
| | Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) |
|
| Conclusion |
|
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