 | | Immunomodulation & island-cell transplantation: Diabetes cured in 7 years? |
|  | | Diabetes mellitus is a beta-cell disease |
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|  | | Immunomodulation - diabetes cured in 7 years? |
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 | | Prevention |
|  | | Prevention |
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 | | Rationale for late intervention: preservation of residual beta-cell function |
|  | | Sustainded beta-cell function is associated with a reduced rate of new-onset albuminuria or worsening of retinopathy |
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 | | Potential late interventions for preservation of beta-cell mass |
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 | | Targeting islet inflammation in de novo type 1 diabetes for β-cell preservation |
|  | | Prevention |
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 | | Islet transplantation - diabetes cured in 7 years? |
|  | | Curing diabetes! Pancreas transplantation |
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 | | Regression of coronary atherosclerosis after pancreas transplantation |
|  | | Benefit of SPK over LDK transplantation in recipients with type 1 diabetes |
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 | | Islet transplantation – since 2007 in the Netherlands (LUMC) (5-10/year) |
|  | | Islet isolation procedure |
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|  | | Transplantation outcome |
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 | | Clinical benefit: chronic diabetic complications |
|  | | Clinical benefit in islet-after kidney: improved kidney graft survival |
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 | | Current options for beta-cell therapy in the LUMC |
|  | | Shortage of organ donors NL 256 (2011) |
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 | | Evidence for islet neogenesis from the duct epithelium in human adults |
|  | | Isolation of human duct cells after islet isolation |
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 | | Intact ducti develop “organoids” in matrigel |
|  | | In vivo differentiation: organoid transplantation under the kidney capsule |
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 | | Organoids under the kidney capsule differentiate to insulin producing cells |
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01.deKoningx (PDF 5,7MB)
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