 | | Novel anticoagulants: How to make a choice? |
|  | | Contents |
|
 | | Indications (N)OACs |
|  | | “Old” versus new |
|
 | | Synthetic oral anticoagulants |
|  | | Indications for NOACs |
|
 | | Arterial and Venous Thrombosis |
|  | | Thrombosis occurs by interaction of three elements |
|
 | | Atherothrombosis |
|  | | Long-term anticoagulation in patients with coronary disease, and future developments. |
|
 | | Long-term anticoagulation in patients with coronary disease, and future developments. |
|  | | Long-term anticoagulation in patients with coronary disease, and future developments. |
|
 | | Median D-dimer concentration over time. |
|  | | Kaplan–Meier curve depicting the primary endpoint |
|
 | | Alexander et al, NEJM 2011 |
|
|
 | | Mega et al, NEJM 2012 |
|
|
 | | So how about these (N)OACs? |
|  | | NOACs in ACS |
|
 | | Is the level of thrombin generated in blood clinically relevant? |
|  | | Atherosclerotic Plaque Progression |
|
 | | Thrombus age after thrombosuction: proportions of treated patients (n=199). |
|  | | Histological spectrum of thrombus and atherosclerotic plaque tissue retrieved by intracoronary thrombectomy. |
|
 | | IF STAININGS – CO-LOCALIZATION OF TF, FVII & FX |
|  | | EARLY ATHEROSCLEROSIS EXHIBITS AN ENHANCED PRO-COAGULANT STATE |
|
 | | SIGNIFICANTLY HIGHER ETP & TAT IN EARLY ATHEROSCLEROTIC LESIONS |
|  | | “What is all that thrombin for?” |
|
 | | Elements of blood coagulation |
|  | | Elements of blood coagulation |
|
 | | PHENOTYPIC MODULATION OF THE ARTERIAL VESSEL WALL: NON-HEMOSTATIC ACTIONS OF KEY COAGULATION PROTEINS |
|  | | Thrombin and atherosclerosis: causality? |
|
 | | Thrombin-induced Atherogenesis? |
|  | | Thrombin being proatherogenic? |
|
 | | EXTENSIVE ATHEROSCLEROSIS IN TM Pro/Pro / ApoE-/- CAROTID ARTERIES |
|  | | INCREASED ACCUMULATION OF MФ AND LESS α-ACTIN AND COLLAGEN I/III IN TM Pro/Pro / ApoE-/- |
|
 | | INTRAPLAQUE HEMORRHAGE & PLAQUE RUPTURE IN TM Pro/Pro / ApoE-/- MICE |
|  | | Secondary prevention |
|
 | | DABIGATRAN/APC PROTECTS AGAINST SEVERE ATHEROSCLEROSIS PROGRESSION IN TM Pro/Pro / ApoE-/- |
|  | | Results I/R injury : Evans Blue/TTC staining |
|
 | | Antithrombotic therapy |
|
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